Trial of Psilocybin versus Escitalopram for Depression

On the basis of the change in depression scores on the QIDS-SR-16 at week 6, this trial did not show a significant difference in antidepressant effects between psilo- cybin and escitalopram in a selected group of patients. Secondary outcomes gener- ally favored psilocybin over escitalopram, but the analyses of these outcomes lacked correction for multiple comparisons.